Abstract: Food security is closely related to national health. Since the global outbreak of COVID-19, the Chinese government has paid more attention to food safety. In order to improve the comprehensive ability and professional quality of undergraduates majoring in food hygiene and nutrition of local medical colleges, Guilin Medical University based on offline course Food hygiene and safety, and combined with outcome-based education concept, curriculum has gradually formed a four-in-one hybrid teaching model including divided classroom, flipped classroom, online learning and curriculum ideology and politics. As a result of continuous exploration and practice, the course has achieved remarkable results in many aspects. The course has officially listed as a school-level offline first-class undergraduate course in 2021.

Key words: Local medical college, First-class course, Food hygiene and safety, OBE