Abstract: In order to improve the employment rate of college graduates, universities should actively explore a mutually beneficial and win-win path of school enterprise cooperation, and cultivate talents with innovative and entrepreneurial abilities. This article elaborates on the important significance of school enterprise cooperation in cultivating college students’innovation and entrepreneurship abilities, analyzes the difficulties in the application of school enterprise cooperation models in cultivating college students'innovation and entrepreneurship abilities, and proposes specific strategies such as adjusting collaborative thinking, strengthening cooperation depth, integrating resources from both parties, and strengthening institutional construction.

Key words: School enterprise cooperation, Innovation and entrepreneurship ability, Collaborative cultivation, Resource integration, Institutional guarantee, College student