Abstract: This article focuses on the problems of mismatched course objectives, fragmented course content, imbalanced course structure, lagging teaching modes, delayed assessment and evaluation, and ineffective mechanism guarantees in the current innovation and entrepreneurship curriculum system. Taking school enterprise collaboration as a powerful tool to cultivate high-quality innovative talents, the article formulates a strategy for reconstructing the innovation and entrepreneurship curriculum system based on the principles of demand driven, collaborative innovation, capability oriented, and dynamic evolution, in order to achieve the new era's innovation and entrepreneurship talent training goals, create an ecosystem of deep integration between the education chain, talent chain, industry chain, and innovation chain, and promote the connotative development of innovation and entrepreneurship talent cultivation in universities in the new era.

Key words: New era, School enterprise collaboration, Resource integration, Innovation and entrepreneurship, Curriculum system, Talent training