Abstract: Innovation and entrepreneurship education in colleges is a crucial pathway for cultivating innovative talents and an integral part of promoting the coordinated and integrated development of education, science and technology, and talent as a “trinity”. Currently, innovation and entrepreneurship education in colleges faces issues such as unclear concepts and understanding, incomplete curriculum systems, weak teaching faculty, inadequate platform construction, and imperfect evaluation and incentive mechanisms. With the advancement of the college academy system reform, innovation and entrepreneurship education is confronted with new development challenges and opportunities. This paper explores innovative concepts, practices, and mechanisms for innovation and entrepreneurship education through five approaches: enhancing educational concepts, integrating courses, empowering mentors, expanding platforms, and exploring mechanisms under the college academy system. It provides practical ideas for integrating innovation and entrepreneurship education into the entire process of talent cultivation within the college academy system and enhancing the quality of innovative talent cultivation in colleges and universities.

Key words: Academy system, Colleges, Innovation and entrepreneurship education, Practical paths, “Three-wide education”, Talent cultivation