Abstract: Cultivating application-oriented innovative talents is a necessary new force in the process of industrialization upgrading, renewal and transformation of all walks of life. Adopting the education mode of integration of specialty and innovation is an excellent way to cultivate application-oriented innovative talents. In view of the lack of close connection between talent training objectives and industrial development, the lack of close combination system between professional courses and practice platform, and the lack of systematic mechanism of evaluation and management in the current integration of colleges and universities, this paper discusses the training path of applied innovative talents based on the perspective of integration of colleges and universities, and constructs a closed loop from students' innovation training, innovation practice, entrepreneurship training to entrepreneurship practice.

Key words: Integration of expertise and innovation, Applied innovative talents, Route