Abstract: Because of the differences in regional administrative affiliation, regional industrial structure and regional educational characteristics, there is no coordination in the establishment of innovation and entrepreneurship education system in colleges and universities in Jiakuntai region of the Yangtze River Delta, there are some problems in resource sharing, such as institutional constraints and concerns. In this paper, the higher vocational colleges in the region of Jiakuntai in the Yangtze River Delta are taken as the research object, and the main problems in setting up the education system of innovation and entrepreneurship and the mechanism of cooperation in the regional colleges and universities are analyzed through discussion and exchange and expert interviews, we should explore the cooperative mechanism of innovation and entrepreneurship education, jointly build high-quality innovation and entrepreneurship teaching team, and share the platform of innovation and entrepreneurship education resources.

Key words: Jiakuntai Region of Yangtze River Delta, Higher vocational college, Innovation and entrepreneurship education, Cooperation