Abstract: As an important part of innovation and entrepreneurship, college students are the foundation of the country's innovation and entrepreneurship and the prosperity of social economy. They are also the key to the implementation of "made in China 2025". All vocational colleges actively respond to national calls and policy guidance, and continue to promote the work of "innovation and entrepreneurship".The purpose of this article is to cultivate talents for innovation in higher vocational education in the Pearl River Delta region, and to focus on cultivating students' awareness and ability in innovation,put forward the construction mode of "six relying on " and the "six modules together" teaching system of dual innovation practice base.Incorporate dual innovation practice courses into talent training programs,establish compulsory courses for all students, and stipulate credit hours.Construct an open and shared environment for dual innovation practice base.Build the practice base into a comprehensive platform integrating education, training, vocational skills appraisal, and technology application and services,efficiently and scientifically serve students' creative activities.

Key words: Innovation and entrepreneurship, Practice base, Construction mode