Abstract: In response to the problems of“curriculum disconnection, resource embeddedness, and inverted evaluation”in innovation and entrepreneurship education for life science majors, this article constructs a“three-level integration, four-dimensional empowerment, and empirical evaluation”model. Through the three-level curriculum system of“foundation core practical”, the integration of“teacher content platform mechanism”four-dimensional ecological empowerment resources, and the ability empirical evaluation mechanism based on eight dimensional literacy, students'innovation practice and industry adaptation abilities are effectively improved. Practice has shown that this model significantly increases students'postgraduate entrance examination rates, employment rates, and the conversion rate of entrepreneurial achievements. It has won 57 awards at or above the provincial level, incubated 2 enterprises, and promoted the conversion of multiple patents and industrial cooperation, forming a replicable and promotable paradigm of integrating innovation and entrepreneurship in education.

Key words: Three level integration, Four-dimensional empowerment, Empirical evaluation, Innovation and entrepreneurship ability, Undergraduate, Training model