Abstract: Innovation and entrepreneurship education is an important part of the country's innovative development. However, the innovation and entrepreneurship curriculum system in colleges and universities lacks systematization, there are relatively few innovation and entrepreneurship practice platforms, and all sectors of society lack the concept and mechanism of collaborative education. The practice teaching system of innovation and entrepreneurship oriented by ability and featuring multiple collaboration clarifies the essential innovation and entrepreneurship abilities that students should possess, and constructs a curriculum system covering basic skills learning, special skills study, innovative skills internship, and vocational skills internship. We have built practice teaching platforms both on and off campus with multiple collaboration. Centering around collaborative education, we have established a collaborative education mechanism with one integrated framework and five mechanisms to ensure the effectiveness of cultivating innovation and entrepreneurship talents.

Key words: Colleges and universities, Ability orientation, Multiple collaboration, Innovation and entrepreneurship education, Practice teaching system, Construction