Abstract: Under the influence of "mass entrepreneurship and innovation" environment, colleges and universities begin to pay attention to the cultivation of entrepreneurship and innovation spirit of college students. However, the effect of Cultivating College Students' innovation and entrepreneurship under the traditional curriculum teaching is not optimistic, so in order to change this situation, we introduce a hybrid teaching mode, and the effect of using this teaching mode to cultivate college students' innovation and entrepreneurship is relatively observable. In this paper, through a brief exposition of the current situation of the course teaching of Cultivating College Students' innovation and entrepreneurship, and the necessity and benefits of improving the teaching mode of Cultivating College Students' innovation and entrepreneurship, and then further explore how to effectively use the mixed teaching mode to cultivate college students' innovation and Entrepreneurship.

Key words: College students, Innovation and entrepreneurship, Hybrid teaching mode, Application