Abstract: In this paper, eight problems existing in innovation and entrepreneurship education in medical higher vocational and undergraduate colleges are studied, and eight ways and paths to solve the problems are found out. Under the guidance of medical innovative thinking and TRIZ innovation method, the innovation and entrepreneurship education methods of the two types of colleges and universities are systematically integrated and applied. After three years of research and practice, the two universities have made great achievements in the construction of innovation and entrepreneurship curriculum, the improvement of College Students' innovation and entrepreneurship ability, the cultivation of innovation and entrepreneurship teachers, the college students' innovation and entrepreneurship competition, the combination of medical professional education and the service of Dawan district's social economy. Research and practice show that medical innovation thinking and TRIZ innovation method lead and guide the innovation and entrepreneurship education of medical colleges and universities, and take the integration of specialty and innovation, production and education, cooperation of own duty and service of local social economy is an effective way and path of entrepreneurship and entrepreneurship education, which highlights the characteristics of Guangzhou.

Key words: TRIZ, Medical innovative thinking, Innovative methods, Application research