Abstract: Under the background of innovation and entrepreneur education, business English subject of Guangdong local universities should build up objective-oriented talent cultivation mechanism which not only can satisfy the development of local economy, but also comply with the foreign language national regulation. Based on the study of market supply and demand, Guangdong local universities should clarify its comparative advantage and set up the talent cultivation mechanism with its own characteristics. The mechanism has five course clusters for different university: international trade, international business management, international finance, international accounting, In order to make correspondence with the development of the local market, it is really important for Guangdong local universities to position the differentiating course clusters, set up application-oriented courses and innovative courses scientifically and cultivate integrated teachers through the deeply cooperation between university and enterprise.

Key words: Guangdong local university, Subject of business English, Professional development, Strategy research