Abstract: This article explores the mechanism of the integrated development of“innovation industry academia research”in higher education, points out the key role of universities in the national innovation system, and analyzes the severe challenges faced by their transformation and upgrading. It provides theoretical support and practical reference for improving the quality of talent cultivation in universities, accelerating the transformation of scientific and technological achievements, and promoting regional economic development; Through summary, it is found that universities have insufficient resource integration in the fields of teaching, research, industry cooperation, and innovation and entrepreneurship education, and there are obvious structural gaps and collaborative obstacles; Based on literature review and empirical analysis, the main driving factors are summarized as national policy guidance, market demand driven, and internal management mechanisms; Four countermeasures are proposed to address these issues: improving policy systems and incentive mechanisms, optimizing internal governance and cultural construction in universities, innovating school enterprise cooperation models, and building regional collaboration platforms.

Key words: Higher education, Collaboration between"innovation, production, academia, and research", "Four in one", Collaborative development mechanism, Mechanism innovation, Regional synergy