Abstract: In recent years, the number of higher education graduates in our country has continued to rise. Therefore, higher vocational colleges need to reform the education management system, personnel training mode and other aspects, so that graduates have stronger employability and entrepreneurial consciousness, and better adapt to the needs of the society. Innovation and entrepreneurship education is an open, complex and systematic education, involving multiple subjects, including the government, enterprises, schools, teachers, students, industries, etc. Higher vocational colleges need to apply collaborative theory, give play to the advantages of multiple subjects, with the goal of promoting students' employment and entrepreneurship, and improve the balance of innovation and entrepreneurship education system. Starting from the theory of collaboration, this paper expounds the practical significance of innovation and entrepreneurship education in higher vocational colleges, and explores the realization path of multiple collaboration to promote the development of innovation and entrepreneurship education.

Key words: Higher vocational colleges, Innovation and entrepreneurship education, Multiple synergy, Path of education, Implementation path, Education mechanism