Abstract: The arrival of the era of "Internet + education" has promoted the reform of higher education teaching. In order to meet the needs of talent training under the new situation, teachers should shift the core of teaching from knowledge teaching to thinking training, and cultivate students' scientific thinking and scientific research exploration ability. This study adopts the mixed teaching mode of "SPOC + micro class + rain class" with teachers as the teaching guide and students as the teaching main body, improve many problems existing in the traditional classroom, such as low students' head up rate, lack of thinking, passive learning, etc., stimulate students' internal drive, and improve the learning effect of the classroom.

Key words: SPOC, Rain class, Micro class, Mixed teaching mode, Pharmaceutical chemistry, Pharmacy