Abstract: First class undergraduate education is to train first-class talents, and first-class majors are the basic units of first-class talents training. Under the background of first-class professional construction, the biotechnology major of Henan Agricultural University has clarified its professional orientation, highlighted its characteristics and advantages, taken multiple measures, deepened comprehensive professional reform, actively explored the professional construction mode of deep integration of innovation and entrepreneurship education and professional education, and established a long-term mechanism for talent training. This paper introduces the measures and results of the construction of the first-class specialty of biotechnology from the aspects of curriculum system, teaching staff, practical teaching and guarantee system.

Key words: Biotechnology, Innovation and entrepreneurship education, First-class specialty, Talent cultivation, Professional education, Agricultural college