Abstract: Information teaching is becoming more and more important in the process of practical teaching. Based on the Zhihuishu network teaching platform, the online and offline hybrid teaching mode of SPOC flipped classroom was explored for the instrumental analysis course of pharmaceutical undergraduates in Henan University. Plan and organize the pre class preview, classroom organizational learning and post class review and discussion, and implement the reform and practice of instrument analysis teaching. Plan and organize the preview, classroom learning, and after-school review processes respectively, and implement the reform practice of instrumental analysis course teaching. It also makes a comprehensive evaluation of the teaching effect, including examination results, students' participation in classroom and online learning, comprehensive ability self-assessment and teaching satisfaction. The results show that the mixed teaching mode has obvious effects in stimulating students' learning interest, cultivating students' innovation ability and cooperation ability, and can effectively improve the quality of curriculum teaching.

Key words: Flipped classroom, Zhihuishu platform, Instrumental analysis