Abstract: In recent years, the job market has been fiercely competitive, and university students' employment difficulties have become prominent. How to cultivate the innovation and entrepreneurship skill of university students is crucial. Using the literature analysis application software system Citespace5.7.R2, this paper takes 969 core journals included in CNKI from 2000 to 2021 as the research object, and makes a graph analysis on the spatial and temporal distribution, keyword clustering and emergence, etc. The results show that: there are abundant research achievements in innovation and entrepreneurship education of college students, but there is a lack of cooperation among researchers; The communication among research institutions is affected by the region, resulting in low degree of closeness and lack of large-scale cross regional cooperation among multi institutions; The research topics are of continuous development, and the academic hotspots are concentrated in the innovation and entrepreneurship teaching, entrepreneurship teaching and innovation of university students. The following reflections are put forward for the future of innovation and entrepreneurship teaching for university students: to carry out large-scale inter-regional cooperation and build a large-scale academic research exchange network. We should firmly grasp the development direction of The Times and extend the depth of the theme of sustainability. We will enhance the effectiveness of innovation and entrepreneurship teaching and build a comprehensive system for educating people in all aspects.

Key words: CiteSpace5.7.R2, A teaching pattern of innovation and entrepreneurship, Knowledge domain