Abstract: The "triple helix" theory provides a new paradigm for the coordination of multi-agent innovation and entrepreneurship education such as government, university and enterprise. Combined with the current practice of entrepreneurship and innovation education in colleges and universities, taking the Sino German Cooperative dual undergraduate project of Chengxian College of Southeast University as a typical case, this paper explores the cooperation path of colleges and universities, government and enterprises in innovation and entrepreneurship education, and takes the "triple helix" theory as a tool, it is of great significance for innovation and entrepreneurship education in colleges and universities to deeply study the mechanism, mode and practice path of the deep integration of innovation and entrepreneurship education and professional education, and explore the collaborative mechanism of "government school enterprise" and other subjects in the integration of innovation and entrepreneurship education and professional education in colleges and universities.

Key words: Triple helix theory, Applied universities, Innovation and entrepreneurship education, Professional education