Abstract: ObjectiveTo explore the research on the cultivation of higher vocational nursing students’ vocational ability under “Big ideological and political education”. Methods368 nursing students of grade 2019 were enrolled in Jiangxi health vocational college from 01/2020 to 01/2021. These students were divided into intervention group (n=283) and control group (n=285) according to the class. The two groups were taught through “clinical ideological and political case” and traditional way in 5 courses. The results, include the achievement in the before and after intervention, “nursing vocational ability evaluation scale” and the comprehensive evaluation of network teaching platform, were statistically analyzed. ResultsCompared with the control group, the intervention group had higher score (85.72±9.37 vs 83.01±10.54),stronger professional quality (26.59±4.73 vs 25.12±5.25), better knowledge level (3.46±3.75 vs 12.59±3.45), better ability (48.56±6.35 vs 47.14±5.47), higher teaching platform score (88.05±9.83 vs 85.82±10.68), the differences were statistically significant (P<0.05). That is to say, it can improve students’ nursing vocational ability that the ideological and political teaching in multiple courses. Conclusion It can improve the nursing vocational ability by the “clinical ideological and political case” under the “Big ideological and political education”.

Key words: Big ideological and political education, Vocational ability, Higher vocation, Nursing