Abstract: In recent years, under the overall arrangement of the education department, the innovation and entrepreneurship education in Colleges and universities has gradually developed and achieved good educational results, which has also been widely recognized by students and society. However, there are still some problems in innovation and entrepreneurship education in some universities, such as imperfect teaching system, insufficient basic investment, lack of teachers, and lack of innovation and entrepreneurship atmosphere. In order to promote the improvement of students' innovation and entrepreneurship ability, we carry out teaching reform in comprehensive practice of e-commerce to realize the development of students' innovation spirit and entrepreneurial quality and ability, and achieve good results.

Key words: Innovation and entrepreneurship, Teaching reform, Comprehensive practice of e-commerce, Education