Abstract: Innovation originates from interest, independence and attempt. Based on "Internet plus" contest of college students' innovative undertaking the creative thinking training course can cultivate students understand the new knowledge, new theory and new method, combining with the previous study in master of chemical basic knowledge, basic theory and basic skills, to improve the practice ability, analysis and problem solving ability, innovation and critical thinking ability. In particular, by following the discipline development, the real problem oriented (in the "scrap disposal and reuse" mushroom bar, for example), the experimental design and research and development, the academic speech and writing, product marketing mode, and other organic combination of practical link, exercise the students' innovative thinking, cultivating students' thinking enterprising spirit, and improve the students' innovation and entrepreneurship.

Key words: "Internet plus" college students innovation and entrepreneurship competition, Innovative thinking training course, Innovation and entrepreneurship ability