Abstract: The deep integration of innovation and entrepreneurship education and professional education has become the main melody of high-quality innovation and entrepreneurship talent training, while classroom teaching is the main channel to cultivate students' entrepreneurial consciousness. However, there is a low integration degree of innovation and entrepreneurship education and professional education in many local application-oriented universities, and there is still a lack of systematic curriculum design for innovation and entrepreneurship education. In this paper, water pollution control engineering course is taken as the carrier, and the organic integration of innovation and entrepreneurship education and professional courses is preliminarily designed and practiced by case teaching method and the opening of the second class, in order to provide reference for the education and teaching reform in colleges and universities and the optimization of "innovation and innovation integration" courses.

Key words: Water pollution control project, Integration of expertise and innovation, Curriculum design, Case teaching method, The second classroom