Abstract: Based on the exploration of the practical teaching system of the integration of professional knowledge and entrepreneurship in the field of international economy and trade, this paper summarizes the problems faced by the integration of professional knowledge and entrepreneurial skills in the field of cross-border e-commerce, such as unclear objectives, repeated content, lack of teaching staff, and division of practice system. At the same time, this paper introduces the experience of international economics and Trade Specialty in Pingdingshan University in the process of exploring the integration of specialty and innovation, and sums up the key points of the integration, namely, clarifying the teaching objectives, optimizing the practical teaching content, strengthening the practical teaching staff and integrating the practical teaching resources of multi specialties. It also takes measures such as driving the practical teaching by competition and combining with post skill training It can inspire other universities and majors.

Key words: Integration of specialty and innovation, Practical teaching, Application-oriented